Key result
Switching from olanzapine to aripiprazole significantly decreased mean resting heart rate from 73.7 to 65.8 beats/min, demonstrating that olanzapine has a stronger heart rate enhancing effect.
Why the study?
Does olanzapine increase resting heart rate compared to aripiprazole or at higher doses in patients with schizophrenia?
Population
48 Japanese outpatients with schizophrenia on stable olanzapine monotherapy, without internal medical…
Comparison
Study 1: Switching from olanzapine to… vs Baseline measurements on initial olanzapine…
Design
Cohort
Follow-up
Study 1: 12.5 ± 10.5 weeks; Study 2: at least 3 weeks on…
Authors
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Olanzapine may elevate resting heart rate versus aripiprazole in schizophrenia; leaves open causal effects on outcomes.
Observational (n=48)
No
Does olanzapine increase resting heart rate compared to aripiprazole or at higher doses in patients with schizophrenia?
Absolute Event Rate: 65.8% vs 73.7%
p-value: p=0.008
Olanzapine has a dose-dependent resting heart rate enhancing effect that is stronger than aripiprazole in patients with schizophrenia.
Tajiri et al. (2018) conducted an observational in Schizophrenia (n=48). Aripiprazole (switch from Olanzapine) vs. Baseline Olanzapine (14.6 ± 9.2 mg/day) was evaluated on Mean resting heart rate (beats/min) (p=0.008). Switching from olanzapine to aripiprazole significantly decreased mean resting heart rate from 73.7 to 65.8 beats/min, demonstrating that olanzapine has a stronger heart rate enhancing effect.
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