Why the study?
Does risperidone compared to olanzapine differentially affect electrocardiographic parameters and blood pressure in patients with schizophrenia?
Population
64 newly diagnosed patients with schizophrenia attending a psychiatry outpatient department in India…
Comparison
Risperidone started at 2 mg/day and increased to… vs Olanzapine started at 5 mg/day and increased to…
Design
Cohort, open label
Follow-up
10 weeks
Authors
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May inform antipsychotic selection by baseline CV risk; leaves open confirmation in randomized trials.
Does risperidone compared to olanzapine differentially affect electrocardiographic parameters and blood pressure in patients with schizophrenia?
Risperidone is associated with mild QTc prolongation and increased heart rate, whereas olanzapine is associated with postural hypotension, highlighting the need for tailored antipsychotic selection based on a patient's baseline cardiovascular risk.
Choure et al. (2014) studied this question.
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