Key result
Short-term administration of olanzapine, risperidone, trifluperazine, and haloperidol produced no statistically significant changes in ECG parameters over 10 days of follow-up.
Why the study?
Does short-term use of olanzapine, risperidone, trifluperazine, or haloperidol affect ECG parameters in psychiatric patients?
Population
71 psychiatric patients requiring the use of antipsychotic drugs
Comparison
Olanzapine, risperidone, trifluperazine, or… vs Baseline ECG values and comparison among the…
Design
Cohort
Follow-up
10 days
Authors
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Supports short-term cardiac safety on ECG; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=71)
Does short-term use of olanzapine, risperidone, trifluperazine, or haloperidol affect ECG parameters in psychiatric patients?
Short-term use (up to 10 days) of commonly used antipsychotic drugs does not significantly alter ECG parameters, suggesting they are safe for short-term use.
Pandurangi et al. (2015) conducted a cohort in Psychiatric patients requiring antipsychotic drugs (n=71). Antipsychotic drugs (Olanzapine, Risperidone, Trifluperazine, Haloperidol) vs. Baseline values was evaluated on ECG parameters. Short-term administration of olanzapine, risperidone, trifluperazine, and haloperidol produced no statistically significant changes in ECG parameters over 10 days of follow-up.
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