Key result
Short-term exercise training for 8 weeks improved resting LVEF from 38% to 44% (p<0.01) and further improved LVEF during acute physical exercise, without changing cardiac energetics.
Why the study?
Does short-term exercise training improve cardiac function and metabolism in patients with heart failure from dilated cardiomyopathy?
Does short-term exercise training improve cardiac function and metabolism in patients with heart failure from dilated cardiomyopathy?
Absolute Event Rate: 44% vs 38%
p-value: p=<0.01
Short-term exercise training improves resting and stress LVEF in patients with dilated cardiomyopathy, particularly in sedentary individuals, without altering cardiac energetics.
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Hypothesis-generating for LVEF gains with exercise in dilated cardiomyopathy; prospective RCTs needed before practice change.
Holloway et al. (2012) studied Heart failure from dilated cardiomyopathy (DCM) (n=15). Cycle exercise training vs. Baseline (before training) was evaluated on Resting left ventricular ejection fraction (LVEF) (p=<0.01). Short-term exercise training for 8 weeks improved resting LVEF from 38% to 44% (p<0.01) and further improved LVEF during acute physical exercise, without changing cardiac energetics.
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