Physical training improves skeletal muscle metabolism in patients with chronic heart failure
Key result
Home-based bicycle training reduces phosphocreatine depletion and ADP increase during exercise in CHF.
- P<0.003
- n=27
Why the study?
Skeletal muscle metabolic abnormalities in chronic heart failure are associated with exercise intolerance, and muscle deconditioning may underlie these metabolic changes.
Population
12 patients with stable ischemic chronic heart failure and 15 age-matched controls
Comparison
8 weeks of home-based bicycle exercise training vs no training
Design
Randomized crossover controlled trial using phosphorus-31 nuclear magnetic resonance spectroscopy
Follow-up
8 weeks
Authors
Discussion
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Overview
Clinical investigation reveals improved skeletal muscle metabolism following physical training in chronic heart failure, highlighting peripheral adaptations to exercise rehabilitation.
Key Points
- To evaluate the effects of physical exercise training on skeletal muscle metabolic capacity in patients suffering from chronic heart failure.
- Assessed skeletal muscle metabolic profiles and functional exercise adaptations in patients diagnosed with chronic heart failure undergoing a physical training intervention.
- Physical training substantially enhances skeletal muscle metabolic function and oxidative capacity in patients with chronic heart failure.
- Exercise intervention alleviates peripheral muscular metabolic abnormalities associated with heart failure progression.
Study Design
Type
RCT (n=27)
Randomization
crossover
PICO
P
Population
12 patients with stable ischemic chronic heart failure and 15 age-matched controls evaluated for skeletal muscle metabolism during an 8-week exercise training program.
I
Intervention / Comparator
home-based bicycle exercise training vs untrained state and age-matched controls
O
Primary Outcome
phosphocreatine depletion and increase in ADP during exercise, p=<0.003
Main Result
p-value: p=<0.003
Cite This Study
Adamopoulos et al. (1993) conducted an RCT in chronic heart failure (n=27). home-based bicycle exercise training vs. untrained state and age-matched controls was evaluated on phosphocreatine depletion and increase in ADP during exercise (p=<0.003). Home-based bicycle exercise training significantly reduced phosphocreatine depletion and ADP increase during exercise in patients with chronic heart failure (p < 0.003).