Key result
A 16-week supervised exercise training program in heart failure patients significantly increased average skeletal muscle mitochondrial size by 23.4% (P<0.015).
Why the study?
Does 16-weeks of supervised exercise training increase skeletal muscle mitochondrial size in chronic heart failure patients?
Does 16-weeks of supervised exercise training increase skeletal muscle mitochondrial size in chronic heart failure patients?
Supervised exercise training in heart failure patients increases skeletal muscle mitochondrial size, which may contribute to improved exercise tolerance.
Mitochondrial enlargement may mediate exercise benefits in HF; hypothesis-generating pending randomized trials.
BACKGROUND: Previous research has demonstrated that exercise intolerance in heart failure patients is associated with significant alterations in skeletal muscle ultrastructure and oxidative metabolism that may be more consequential than cardiac output. DESIGN: To examine the effect of exercise training on skeletal muscle mitochondrial size in chronic heart failure patients. METHODS: Six heart failure patients participated in 16-weeks of supervised upper and lower extremity exercise training. At the conclusion of training, percutaneous needle biopsies of the vastus lateralis were taken and electron microscopy was used to assess mitochondrial sizes. RESULTS: The exercise programme resulted in a significant increase in peak maximal oxygen consumption ( P< 0.05) and anaerobic threshold (P < 0.04). Knee extension muscle force increased following training ( P< 0.02). After exercise training, the average size of the mitochondria increased by 23.4% (0.036 to 0.046 mu(2), P< 0.015) and the average shape was unaltered. CONCLUSION: Exercise training with heart failure patients alters skeletal muscle morphology by increasing mitochondrial size, with no change in shape. This may enhance oxidative metabolism resulting in an increased exercise tolerance.
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Santoro et al. (2002) studied Chronic heart failure (n=6). Supervised upper and lower extremity exercise training vs. Pre-training baseline was evaluated on Skeletal muscle mitochondrial size (23.4% increase, p=< 0.015). A 16-week supervised exercise training program in heart failure patients significantly increased average skeletal muscle mitochondrial size by 23.4% (P<0.015).
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