Aortic valve replacement with INSPIRIS RESILIA yielded similar mid-term safety and performance compared to PERIMOUNT MAGNA EASE in patients under 70, with 3-year mortality of 0% vs 1.9%.
Observational (n=300)
No
Does the INSPIRIS RESILIA bioprosthetic aortic valve improve clinical and echocardiographic outcomes compared to the PERIMOUNT MAGNA EASE valve in patients under 70 undergoing surgical aortic valve replacement?
The INSPIRIS RESILIA and PERIMOUNT MAGNA EASE bioprosthetic valves demonstrate similar mid-term safety and haemodynamic performance in patients under 70 years of age.
Absolute Event Rate: 0% vs 1.9%
OBJECTIVES: INSPIRIS RESILIA, launched in 2017, is a bioprosthetic aortic valve developed to improve durability and facilitate future valve-in-valve procedures. Despite its advanced design, many surgeons continue to use the PERIMOUNT MAGNA EASE valve, which has long-standing clinical validation. This study aimed to compare mid-term clinical and echocardiographic outcomes in patients under 70 undergoing aortic valve replacement with either prosthesis. METHODS: We conducted a retrospective study of patients who underwent surgical aortic valve replacement between January 2018 and May 2023 at the University Hospital of Reims. The primary outcome was all-cause mortality at 1 year following surgical aortic valve replacement. Secondary outcomes included haemodynamic parameters, left ventricular ejection fraction, and major postoperative complications such as reintervention, stroke, pacemaker implantation, mediastinitis, transfusion, and new-onset atrial fibrillation. RESULTS: A total of 300 patients were included: 52 received the INSPIRIS RESILIA valve and 248 received the PERIMOUNT MAGNA EASE valve. After matching, 52 patients from each group were compared. All-cause mortality at 3 years was 0% in the INSPIRIS group and 1.9% in the PERIMOUNT group. Mean transvalvular gradients were similar at 1 year (11.3 vs 11.2 mmHg) and 3 years (12.9 mmHg for both). Two cases of endocarditis-related reoperation occurred in the INSPIRIS group. No structural valve degeneration requiring surgery was observed. Postoperative aortic regurgitation was trivial or absent. Transfusion rates were lower in the INSPIRIS group (46.1% vs 69.2%, P = .017). CONCLUSIONS: INSPIRIS RESILIA and MAGNA EASE valves offer similar mid-term safety and performance in patients under 70 years of age.
Saiydoun et al. (Fri,) conducted a observational in Aortic valve replacement (n=300). INSPIRIS RESILIA bioprosthesis vs. PERIMOUNT MAGNA EASE bioprosthesis was evaluated on All-cause mortality at 1 year following surgical aortic valve replacement. Aortic valve replacement with INSPIRIS RESILIA yielded similar mid-term safety and performance compared to PERIMOUNT MAGNA EASE in patients under 70, with 3-year mortality of 0% vs 1.9%.