Real-world early- to midterm outcomes of aortic valve replacement using novel tissue technology bioprosthesis at a high-volume center

Figures

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  Freedom from reoperation after AVR with INSPIRIS-RESILIA versus PERIMOUNT valves, 97% CI.

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  Figure 1. Postoperative hemodynamics of INSPIRIS-RESILIA valve. Solid lines represent longitudinal trend in aortic regurgitation grades and mean gradient. Symbols represent data grouped (without regard to repeated measurements) within time frames to provide a crude verification of model fit. Number of patients who had follow-up echocardiogram within yearly intervals is given under the horizontal axis. A, Prevalence of aortic regurgitation (AR). B, Temporal trend of mean gradient across the aortic valve (AV).

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  Figure 2. Time-related outcomes after aortic valve replacement with INSPIRIS-RESILIA prosthesis. The solid line is parametric estimate enclosed within dashed 68% CI. Each symbol represents a Kaplan-Meier estimate of the event, and vertical bars are 68% confidence limits equivalent to ±1 standard error. Numbers below the horizontal axis are patients remaining at risk. A, Freedom from reoperation after aortic valve replacement with INSPIRIS-RESILIA valve. B, Survival after aortic valve replacement with INSPIRIS-RESILIA valve.

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  Figure 3. Postoperative hemodynamics of INSPIRIS-RESILIA and PERIMOUNT valves in the matched cohorts. Solid lines represent longitudinal trend in aortic regurgitation grades and mean gradient. Symbols represent data grouped (without regard to repeated measurements) within time frames to provide a crude verification of model fit. Number of patients who had follow-up echocardiogram within yearly intervals is given under the horizontal axis. A, Prevalence of aortic regurgitation (AR). B, Temporal trend of mean gradient across the aortic valve (AV).

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  Figure 4. Time-related outcomes after aortic valve replacement with INSPIRIS-RESILIA versus PERIMOUNT prosthesis in the matched cohorts. The solid line is a parametric estimate enclosed within dashed 68% CI. Each symbol represents a Kaplan-Meier estimate of the event, and vertical bars are 68% confidence limits equivalent to ±1 standard error. Numbers below the horizontal axis are patients remaining at risk. A, Freedom from reoperation after aortic valve replacement with INSPIRIS-RESILIA versus PERIMOUNT valves. B, Survival after surgery.

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  Figure E1. Consolidated Standards of Reporting Trials–style diagram of patients undergoing aortic valve replacement with INSPIRIS-RESILIA versus PERIMOUNT prostheses. VAD, Ventricular assist device; TAVR, transcatheter aortic valve replacement.

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  Figure E2. Temporal trend of number of patients undergoing aortic valve replacement with INSPIRIS-RESILIA prosthesis (INSPIRIS-RESILIA; blue lines and symbols) and PERIMOUNT prosthesis (PERIMOUNT; red lines and symbols) over the study period. Symbols are yearly number of cases in each group.

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  Figure E3. Completeness of echocardiogram follow-up. The follow-up is regarded as complete when the blue circles are closer to the diagonal. A, Follow-up for the INSPIRIS-RESILIA cohort. It can be noted that INSPIRIS-RESILIA cases are more recent; thus, the maximum follow-up is limited. Further, more recent cases (after the year 2023), appear to have less follow-up. B, Follow-up of the matched PERIMOUNT cohort.

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  Figure E4. Quality of balancing score matching of patients undergoing aortic valve replacement with INSPIRIS-RESILIA prosthesis and PERIMOUNT prosthesis. A, Standardized differences of selected variables before and after matching. Vertical dashed lines at −0.1 and +0.1 indicate boundaries of desirable matching. B, Mirrored histogram of distribution of balancing scores for both groups (INSPIRIS-RESILIA; blue bars; PERIMOUNT; red bars). Shaded areas represent matched patient pairs and depict the spectrum of the matched patients. GFR, Glomerular filtration rate; LV, left ventricular; CVA, cerebrovascular accident; TV, tricuspid valve; MV, mitral valve; BSA, body surface area.

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  Figure E5. Postoperative hemodynamics stratified by prosthesis size in the matched cohorts. Temporal trend of mean gradient across the aortic valve (AV). Solid lines represent longitudinal trend in mean gradient. Symbols represent data grouped (without regard to repeated measurements) within time frames to provide a crude verification of model fit. A, Matched INSPIRIS-RESILIA valve cohort. B, Matched PERIMOUNT cohort.