Prosthesis Oversizing in Balloon-Expandable Transcatheter Aortic Valve Implantation Is Associated With Contained Rupture of the Aortic Root
Key result
Severe prosthesis oversizing (24.6% vs 9.1%; P<0.001) was significantly associated with contained rupture of the aortic root in patients undergoing balloon-expandable TAVI.
Why the study?
Does prosthesis oversizing increase the risk of contained rupture of the aortic root in patients undergoing balloon-expandable TAVI?
Population
72 patients undergoing balloon-expandable TAVI, mean age 82±7 years, mean aortic valve area 0.69±0.19 cm2.
Design
Cohort
Authors
Discussion
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Member takes
Implication
Severe oversizing may heighten contained rupture risk in balloon-expandable TAVI; leaves open optimal CT sizing thresholds.
Study Design
Type
Observational (n=72)
Structured PICO
Does prosthesis oversizing increase the risk of contained rupture of the aortic root in patients undergoing balloon-expandable TAVI?
P
Population
72 patients undergoing balloon-expandable TAVI, mean age 82±7 years, mean aortic valve area 0.69±0.19 cm2.
I
Intervention
Balloon-expandable transcatheter aortic valve implantation (TAVI) using a balloon-expandable transcatheter heart valve (23 mm, 26 mm, or 29 mm)
O
Outcome
Contained rupture of the aortic root diagnosed by post-TAVI multislice computed tomographysafety
Main Result
Absolute Event Rate: 24.6% vs 9.1%
p-value: p=<0.001
Severe prosthesis oversizing during balloon-expandable TAVI is strongly associated with contained rupture of the aortic root, highlighting the importance of accurate CT-based sizing.
Cite This Study
Blanke et al. (2012) conducted an observational in Aortic stenosis (n=72). Balloon-expandable TAVI (Edwards SAPIEN) was evaluated on Relative prosthesis oversizing in patients with vs without contained aortic root rupture (p=<0.001). Severe prosthesis oversizing (24.6% vs 9.1%; P<0.001) was significantly associated with contained rupture of the aortic root in patients undergoing balloon-expandable TAVI.