Association of Ventricular Arrhythmias With Dementia
View Full Paper
Ask AI
Bookmark
Share
Key result
NSVT linked to ~267% higher dementia odds in Black but not White participants.
- OR 3.67
- 95% CI 1.92-7.02
- P<0.001
- n=2,517
Why the study?
It was unknown whether nonsustained ventricular tachycardia and premature ventricular contractions are associated with dementia in a population-based setting.
Does the presence and burden of NSVT and PVCs increase the odds of dementia in an elderly population?
Population
2,517 participants (mean age 79 years, 26% Black) undergoing 2-week continuous ECG monitoring
Comparison
Presence and burden of NSVT and PVCs vs absence or lower burden
Design
Population-based cross-sectional study
Authors
Discussion
Loading...
Member takes
Implication
Does not support practice change; leaves open race-specific NSVT-dementia links for prospective validation.
Key Points
- To determine whether nonsustained ventricular tachycardia (NSVT) and premature ventricular contractions (PVCs) associate with dementia in a population-based cohort.
- Evaluated 2,517 participants (mean age 79 years, 26% Black) who wore a 2-week ambulatory continuous ECG recording patch (mean duration 12.6 ± 2.6 days) between 2016 and 2017.
- Quantified NSVT (wide-complex tachycardia ≥4 beats at >100 bpm) and PVC daily burden, assessing their relationship with expert-adjudicated dementia using multivariable logistic regression.
- NSVT was present in 31% of participants (768 individuals), and dementia was diagnosed in 6.5% of cases (5% in White participants, 10% in Black participants).
- Multivariable models showed no overall association between NSVT and dementia, but revealed a significant race interaction (p < 0.001).
- In Black participants, NSVT was associated with significantly higher odds of dementia (OR 3.67, 95% CI 1.92–7.02) and higher PVC burden also correlated with dementia, whereas no association was observed in White participants (OR 0.64, 95% CI 0.37–1.10).
Study Design
Type
Cross-Sectional (n=2,517)
Structured PICO
Does the presence and burden of NSVT and PVCs increase the odds of dementia in an elderly population?
P
Population
2,517 elderly adults (mean age 79 years, 58% female, 26% Black) from the Atherosclerosis Risk in Communities (ARIC) study cohort (visit 6) who wore a 2-week ambulatory continuous ECG recording device.
I
Intervention
Presence and higher burden of nonsustained ventricular tachycardia (NSVT) and premature ventricular contractions (PVCs) detected via 2-week continuous ambulatory ECG monitoring (Zio XT Patch).
C
Comparator
Absence of NSVT/PVCs or lower burden of NSVT/PVCs.
O
Outcome
Dementia, adjudicated by an expert panel based on a comprehensive neurocognitive battery, neurologic history, and interviews.hard clinical
Main Result
Effect estimate: OR 3.67 (95% CI 1.92-7.02)
p-value: p=<0.001
Limitations
- Power was very limited in the subset analysis for brain MRI.
Cite This Study
Norby et al. (2020) conducted a cross-sectional in Dementia (n=2,517). Nonsustained ventricular tachycardia (NSVT) and premature ventricular contractions (PVCs) vs. Absence of NSVT/PVCs was evaluated on Dementia (OR 3.67, 95% CI 1.92-7.02, p=<0.001). Nonsustained ventricular tachycardia was associated with higher odds of dementia in Black participants (OR 3.67; 95% CI 1.92–7.02), but not in White participants (OR 0.64; 95% CI 0.37–1.10).
Topics
View Full Paper
Ask AI
Bookmark
Share