Key result
Elevated RDW is linked to greater daytime blood pressure variability in hypertensive patients.
Why the study?
RDW is independently associated with worse cardiovascular outcomes and may reflect systemic inflammation, but its correlation with blood pressure variability in hypertensive patients required investigation.
Is red cell distribution width associated with blood pressure variability in patients with essential hypertension?
Observational (n=210)
Is red cell distribution width associated with blood pressure variability in patients with essential hypertension?
Elevated red cell distribution width is positively correlated with daytime blood pressure variability in patients with essential hypertension, suggesting a potential link between systemic inflammation and blood pressure fluctuations.
Answers are grounded in this paper and cite their sources.
RDW was associated with daytime BP variability in hypertension; hypothesis-generating, requires longitudinal confirmation before clinical consideration.
BACKGROUND/AIMS: The relation between blood pressure variability and inflammation has been demonstrated in numerous types of research.Red cell distribution width (RDW) is independently related to worse cardiovascular consequences.An increased RDW in the circulation may project continuing systemic and vascular inflammatory processes and contribute to the development of hypertension.We purposed to research the correlation between RDW and blood pressure variability in hypertensive patients.MATERIALS AND METHODS: Our research included 210 participants with essential hypertension.Hypertensive participants were identified according to the current guidelines.Twenty-four-hour ambulatory blood pressure monitoring (24-hABPM) was done for each participant.Since variability values are parallel with standard deviation values, statistical analysis was done over standard deviation.Routine biochemistry analyses and complete blood count were also done.The Contribution of independent variables on blood pressure variability was analyzed by stepwise multivariable lineer regression analysis RESULTS: A Positive statistical correlation was found between RDW levels and daytime systolic blood pressure variability, and also diastolic blood pressure variability (R=0.198,p=0.002 and R=0.101, p=0.004; in order of), similarly, positive correlation were found between variables (female, DM, smoking) (R=0.202,p=0.002;R=0.130, p=0.042;R=0.181, p=0.004; in order of) both for daytime systolic and diastolic blood pressure variability (R=0.186,p=0.005;R=0.192, p=0.004;R=0.191, p=0.004; in order of).Although a strong positive statistical correlation (p <0.001) was found between age and daytime systolic blood pressure, no correlation was detected between age and daytime diastolic blood pressure variability.CONCLUSION: Elevated RDW value predicts daytime blood pressure variability in hypertensive patients.This relation may depend on the underlying inflammation.Further research is needed to survey the influences of strict blood pressure control on adverse cardiovascular events via inflammation and blood pressure variability.
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Mehmet Ali Mendi (2024) conducted an observational in essential hypertension (n=210). Red cell distribution width (RDW) was evaluated on daytime systolic and diastolic blood pressure variability (R=0.198 (systolic), R=0.101 (diastolic), p=0.002 and 0.004). Elevated red cell distribution width was positively correlated with daytime systolic (R=0.198, p=0.002) and diastolic (R=0.101, p=0.004) blood pressure variability in hypertensive patients.
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