Key result
Metabolic syndrome was associated with a higher prevalence of non-dipping blood pressure compared to subjects without the syndrome (50% vs 31%).
Why the study?
Is metabolic syndrome associated with a higher prevalence of non-dipping blood pressure in Omani Arabs?
Cross-Sectional (n=1,124)
Is metabolic syndrome associated with a higher prevalence of non-dipping blood pressure in Omani Arabs?
Metabolic syndrome is associated with a significantly higher prevalence of non-dipping blood pressure, with high BMI and triglycerides identified as key determinants, potentially adding to the cardiovascular burden.
Answers are grounded in this paper and cite their sources.
May support ambulatory BP monitoring in metabolic syndrome; leaves open prospective validation of outcomes.
OBJECTIVE: The objective was to examine the circadian changes in blood pressure and their relation to the metabolic syndrome and its components in Omani Arabs. RESEARCH METHODS AND PROCEDURES: Ambulatory blood pressure (ABPM) was recorded in 1124 subjects from 5 large, extended, consanguineous, and young Arab pedigrees. According to the International Diabetes Federation's definition, 264 subjects had the metabolic syndrome, a prevalence of 23%. Subjects were defined as non-dippers when their nocturnal systolic blood pressure (SBP) fell by <10% from daytime SBP. RESULTS: Non-dippers with the metabolic syndrome were 131 of 264 (50%), compared with 265 of 860 (31%) without the metabolic syndrome. Of the non-dippers, 99 of 131 (76%) were females and 32 of 131 (24%) were males. Daytime and nighttime SBP and DBP and nighttime pulse pressure were significantly higher in non-dipper subjects with the metabolic syndrome. The important determinants of a non-dipping BP in this cohort were high BMI and high serum triglycerides. DISCUSSION: We hypothesize that obesity and nocturnal volume-dependent hypertension may be involved in the pathophysiology of non-dipping in the metabolic syndrome. This study showed that non-dipping BP was common in subjects with the metabolic syndrome. Higher 24-hour blood pressure load may add to the indices of the overall cardiovascular burden already associated with the metabolic syndrome.
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Hassan et al. (2007) conducted a cross-sectional in Metabolic syndrome (n=1,124). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Non-dipping blood pressure (nocturnal SBP fall <10% from daytime SBP). Metabolic syndrome was associated with a higher prevalence of non-dipping blood pressure compared to subjects without the syndrome (50% vs 31%).
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