Key result
Percutaneous transluminal coronary angioplasty significantly increased A-wave transit time from 57 +/- 5 ms to 78 +/- 7 ms within 24 hours, indicating early improvement in diastolic compliance.
Why the study?
Does percutaneous transluminal coronary angioplasty improve early Doppler echocardiographic indexes of left ventricular diastolic function in patients with isolated severe left anterior descending coronary artery stenosis?
Observational (n=30)
Does percutaneous transluminal coronary angioplasty improve early Doppler echocardiographic indexes of left ventricular diastolic function in patients with isolated severe left anterior descending coronary artery stenosis?
Successful coronary angioplasty leads to early improvement in left ventricular diastolic compliance as measured by A-wave transit time on Doppler echocardiography.
Answers are grounded in this paper and cite their sources.
May support early diastolic gains post-PTCA in LAD stenosis; leaves open need for randomized outcome trials.
AIMS: The early effect of percutaneous transluminal coronary angioplasty on left ventricular diastolic dysfunction was investigated with the aid of new Doppler echocardiographic applications. METHODS: Thirty patients with isolated severe left anterior descending coronary artery stenosis were included. All patients exhibited abnormal diastolic function demonstrated by prolonged isovolumic relaxation and deceleration time and decreased E/A ratio. New Doppler indexes included the flow propagation velocity of E wave, E and A waves' transit time to the left ventricular outflow tract, the ratio of these transit times in addition to the traditional isovolumic relaxation time, mitral deceleration time, and early and late transmitral peak flow velocities. All measurements were performed within 4 h before angioplasty and repeated within 24 h after the procedure. RESULTS: After angioplasty none of these parameters, except the A-wave transit time, were changed significantly. The A-wave transit time increased significantly from 57 +/- 5 ms to 78 +/- 7 ms within 24 h after successful angioplasty. The ratio of E- and A-wave transit time decreased significantly due to this significant increase in A-wave transit time. CONCLUSION: In this study, early improvement of Doppler index of left ventricular diastolic compliance is demonstrated after successful angioplasty.
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Serdar Bayata (2000) conducted an observational in Isolated severe left anterior descending coronary artery stenosis with abnormal diastolic function (n=30). Percutaneous transluminal coronary angioplasty vs. Baseline (before angioplasty) was evaluated on A-wave transit time to the left ventricular outflow tract. Percutaneous transluminal coronary angioplasty significantly increased A-wave transit time from 57 +/- 5 ms to 78 +/- 7 ms within 24 hours, indicating early improvement in diastolic compliance.
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