Key result
Successful single vessel coronary angioplasty significantly shortened isovolumic relaxation time from 75 ms to 64 ms (p<0.001) and improved left ventricular long axis function.
Why the study?
Does single vessel coronary angioplasty improve resting left ventricular long axis function in patients with significant left coronary disease?
Population
23 patients with significant left coronary disease being considered for coronary angioplasty
Comparison
Single vessel coronary angioplasty vs Baseline (before angioplasty)
Design
Cohort
Follow-up
early after angioplasty
Authors
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Supports reversible LV long-axis dysfunction from single-vessel stenosis; hypothesis-generating for functional recovery, pending randomized confirmation.
Observational (n=23)
No
Does single vessel coronary angioplasty improve resting left ventricular long axis function in patients with significant left coronary disease?
Absolute Event Rate: 64% vs 75%
p-value: p=<0.001
Successful single vessel coronary angioplasty acutely improves resting left ventricular long axis systolic and diastolic function, suggesting these abnormalities are directly caused by coronary stenosis.
Henein et al. (1993) conducted an observational in coronary artery disease (n=23). single vessel coronary angioplasty vs. baseline (before angioplasty) was evaluated on isovolumic relaxation time (ms) (p=<0.001). Successful single vessel coronary angioplasty significantly shortened isovolumic relaxation time from 75 ms to 64 ms (p<0.001) and improved left ventricular long axis function.
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