Key result
Spironolactone 25 mg daily significantly reduced mean daytime systolic blood pressure by 5.4 mmHg compared to placebo in patients with resistant arterial hypertension.
Why the study?
Does spironolactone reduce blood pressure in patients with resistant arterial hypertension?
Does spironolactone reduce blood pressure in patients with resistant arterial hypertension?
Effect estimate: Mean difference -5.4 (95% CI -10.0; -0.8)
Absolute Event Rate: -9.3% vs -3.9%
p-value: p=0.024
This review highlights that while spironolactone reduces systolic blood pressure in resistant hypertension, its absolute effect in randomized trials is smaller than previously suggested by observational studies.
May support use in resistant hypertension; challenges larger effects suggested by observational data.
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Václavík et al. (2011) conducted a review in Resistant arterial hypertension (n=117). Spironolactone vs. Placebo was evaluated on Decrease in mean daytime systolic blood pressure on ABPM (Mean difference -5.4, 95% CI -10.0; -0.8, p=0.024). Spironolactone 25 mg daily significantly reduced mean daytime systolic blood pressure by 5.4 mmHg compared to placebo in patients with resistant arterial hypertension.
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