Why the study?
Does high-dose spironolactone change renin and aldosterone levels in patients with acutely decompensated heart failure?
Does high-dose spironolactone change renin and aldosterone levels in patients with acutely decompensated heart failure?
High-dose spironolactone added to standard therapy in acutely decompensated heart failure significantly increases renin and aldosterone concentrations by day 3.
May prompt RAAS monitoring with high-dose spironolactone in ADHF; hypothesis-generating and leaves clinical effects open pending RCTs.
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Ferreira et al. (2014) studied this question.
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