Contrast-enhanced three-dimensional dobutamine stress echocardiography: between Scylla and Charybdis?
Key result
Contrast-enhanced stress RT3DE demonstrated moderate diagnostic accuracy for detecting significant coronary artery disease, with 61% sensitivity and 88% specificity compared to coronary angiography.
Why the study?
Does contrast-enhanced stress RT3DE accurately detect significant coronary artery disease compared to coronary arteriography in patients referred for angiography?
Population
45 consecutive patients referred for coronary angiography, mean age 59 +/- 10, 31 males.
Comparison
Contrast-enhanced stress real-time… vs Coronary arteriography and conventional RT3DE
Design
Cross-sectional
Authors
Discussion
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Implication
Moderate sensitivity precludes clinical adoption for CAD detection; leaves open need for resolution improvements in prospective studies.
Study Design
Type
Observational (n=45)
Structured PICO
Does contrast-enhanced stress RT3DE accurately detect significant coronary artery disease compared to coronary arteriography in patients referred for angiography?
P
Population
45 consecutive patients referred for coronary angiography, mean age 59 +/- 10, 31 males.
I
Intervention
Contrast-enhanced stress real-time three-dimensional echocardiography (RT3DE)
C
Comparator
Coronary arteriography (as reference standard) and conventional RT3DE (in a subset of 35 patients)
O
Outcome
Diagnostic accuracy (sensitivity and specificity) for detection of significant coronary artery diseasesurrogate
Contrast-enhanced stress RT3DE has only moderate diagnostic sensitivity for detecting CAD due to technical limitations in temporal and spatial resolution, despite improving image quality and interobserver agreement compared to conventional RT3DE.
Limitations
- Technical limitations such as temporal and spatial resolution
Cite This Study
Krenning et al. (2008) conducted an observational in Coronary artery disease (n=45). Contrast-enhanced stress real-time three-dimensional echocardiography (RT3DE) vs. Coronary arteriography and conventional RT3DE was evaluated on Detection of significant coronary artery disease. Contrast-enhanced stress RT3DE demonstrated moderate diagnostic accuracy for detecting significant coronary artery disease, with 61% sensitivity and 88% specificity compared to coronary angiography.