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April 24, 1987JAMA

Cholesterol and mortality. 30 years of follow-up from the Framingham study

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Authors

KAKeaven M. AndersonGeneral / Preventive / Lipids

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Implication

Prospective cohort study observes age-dependent mortality risk from cholesterol levels in adults, highlighting differing cardiovascular impacts across lifespans.

Key Points

  • To assess the relationship between serum cholesterol levels, cholesterol trajectory over time, and 30-year overall and cardiovascular disease mortality.
  • Prospective cohort study examining 1,959 men and 2,415 women aged 31 to 65 years who were initially free of cardiovascular disease and cancer between 1951 and 1955.
  • Follow-up conducted over 30 years from the Framingham study, evaluating baseline cholesterol levels and cholesterol trajectory over the first 14 years in relation to subsequent mortality.
  • In participants under 50 years old, overall mortality increased by 5% and CVD mortality increased by 9% for each 10 mg/dL increment in serum cholesterol.
  • In participants older than 50 years, baseline cholesterol was not associated with increased overall mortality for either high or low levels.
  • A decline in cholesterol levels over the first 14 years was directly associated with higher mortality over the subsequent 18 years, showing an 11% overall and 14% CVD death rate increase per 1 mg/dL per year drop.

Cite This Study

Keaven M. Anderson (1987) studied this question.

synapsesocial.com/papers/6a1567b437103a43379fb03ehttps://doi.org/10.1001/jama.257.16.2176
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Also Consider

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  1. 1Epidemiological Approaches to Heart Disease: The Framingham Study1951 · 2,187 citations
  2. 2Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)1986 · 1,997 citations
  3. 3A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITY1952 · 3,095 citations
  4. 4Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study1986 · 2,309 citations
  5. 5ON A POSSIBLE INVERSE RELATIONSHIP BETWEEN SERUM CHOLESTEROL AND CANCER MORTALITY1981 · 79 citations