Key result
Angiotensin II and low-sodium diet increased proliferation of zona glomerulosa endothelial cells, with losartan preventing ANG II-induced hyperplasia but not the effects of a low-sodium diet.
Why the study?
How do angiotensin II, losartan, and a low-sodium diet affect adrenal cell proliferation in rats?
How do angiotensin II, losartan, and a low-sodium diet affect adrenal cell proliferation in rats?
Cell hypertrophy and proliferation of glomerulosa cells are mediated by both AT1 receptor-dependent and -independent processes, while reticularis cell proliferation is controlled by AT1 receptors.
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Rat adrenal data suggest no immediate change to ARB use; leaves open AT1-independent mechanisms in low-sodium responses.
McEwan et al. (1999) studied Adrenal cell proliferation. Angiotensin II, losartan, and low-sodium diet vs. Control was evaluated on Adrenal cell proliferation. Angiotensin II and low-sodium diet increased proliferation of zona glomerulosa endothelial cells, with losartan preventing ANG II-induced hyperplasia but not the effects of a low-sodium diet.
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