Key result
Angiotensin II and sodium restriction caused a two- to threefold increase in BrdUrd indexes in the zona glomerulosa, indicating specific control of cell proliferation by ANG II.
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May inform adrenal adaptation models; leaves open clinical translation to aldosterone disorders.
McEwan et al. (1996) studied this question. Angiotensin II, high/low sodium intake, and captopril was evaluated on Cell proliferation assessed as uptake of 5-bromo-2'-deoxyuridine (BrdUrd) into nuclei. Angiotensin II and sodium restriction caused a two- to threefold increase in BrdUrd indexes in the zona glomerulosa, indicating specific control of cell proliferation by ANG II.
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