Key result
Long-term administration of captopril in normal rats induced notable atrophy of zona glomerulosa cells and significantly lowered plasma aldosterone concentration, effects reversed by angiotensin II.
Why the study?
Does long-term captopril administration alter the morphology and steroidogenic capacity of the normal rat adrenal zona glomerulosa?
Does long-term captopril administration alter the morphology and steroidogenic capacity of the normal rat adrenal zona glomerulosa?
Captopril induces atrophy of the rat adrenal zona glomerulosa and reduces aldosterone secretion, confirming the dependence of this tissue on the renin-angiotensin system.
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Cautions against clinical extrapolation from rat data; confirms renin-angiotensin dependence of zona glomerulosa morphology in this model.
Mazzocchi et al. (2009) studied Normal rat adrenal zona glomerulosa. Captopril (Squib 14225) was evaluated on Morphology of zona glomerulosa cells and plasma aldosterone concentration. Long-term administration of captopril in normal rats induced notable atrophy of zona glomerulosa cells and significantly lowered plasma aldosterone concentration, effects reversed by angiotensin II.
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