Key result
Recent findings highlight the renin-angiotensin system as a complex cascade with multiple mediators and receptors, emphasizing the putative role of the ACE2-Ang-(1-7)-Mas axis in diabetes pathogenesis.
This review highlights the evolving complexity of the renin-angiotensin system, particularly the ACE2-Ang-(1-7)-Mas axis, and its implications for endothelial function and insulin signaling in diabetes.
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Does not alter diabetes management; extends RAS complexity understanding and leaves open therapeutic targeting of the ACE2-Ang-(1-7)-Mas axis.
In the past few years the classical concept of the renin–angiotensin system (RAS) has experienced substantial conceptual changes. The identification of the renin/prorenin receptor, the angiotensin-converting enzyme homologue ACE2 as an angiotensin peptide processing enzyme, Mas as a receptor for Ang-(1-7) and the possibility of signaling through ACE, have contributed to switch our understanding of the RAS from the classical limited-proteolysis linear cascade to a cascade with multiple mediators, multiple receptors, and multi-functional enzymes. In this review we will focus on the recent findings related to RAS and, in particular, on its role in diabetes by discussing possible interactions between RAS mediators, endothelium function, and insulin signaling transduction pathways as well as the putative role of ACE2-Ang-(1-7)-Mas axis in disease pathogenesis.
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Ana Cristina Simões e Silva (2008) conducted a review in Diabetes. Renin-angiotensin system (RAS) mediators was evaluated. Recent findings highlight the renin-angiotensin system as a complex cascade with multiple mediators and receptors, emphasizing the putative role of the ACE2-Ang-(1-7)-Mas axis in diabetes pathogenesis.
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