Key result
The 1991-1995 young men cohort is associated with ~50% lower CVD mortality but increased heart failure.
Why the study?
Heart failure and stroke incidence are increasing in young people despite decreasing overall CHD and CVD mortality, potentially due to rising obesity and reduced cardiorespiratory fitness.
Cohort (n=1,258,432)
Effect estimate: HR 0.50 (for CVD mortality) (95% CI 0.42-0.59)
In young Swedish men, there has been a marked secular shift from AMI and CVD mortality to increased incidence of heart failure and stroke, partially driven by rising obesity and declining fitness.
Declining CVD mortality in young men coincides with rising HF and stroke; leaves open whether obesity and fitness drive the shift.
BACKGROUND: As opposed to the decreasing overall rates of coronary heart disease (CHD) incidence and overall cardiovascular disease (CVD) mortality, heart failure (HF) and stroke incidence are increasing in young people, potentially due to rising rates of obesity and reduced cardiorespiratory fitness (CRF). OBJECTIVES: We investigated trends in early major CVD outcomes in a large cohort of young men. METHODS: Successive cohorts of Swedish military conscripts from 1971 to 1995 (N = 1,258,432; mean age, 18.3 years) were followed, using data from the National Inpatient and Cause of Death registries. Cox proportional hazard models were used to analyse changes in 21-year CVD event rates. RESULTS: 21-year CVD and all-cause mortality and incidence of acute myocardial infarction (AMI) decreased progressively. Compared with the cohort conscripted in 1971-1975 (reference), the hazard ratios (HRs) for the last 1991-1995 cohort were 0.50 [95% confidence interval (CI) 0.42-0.59] for CVD mortality; 0.57 (95% CI 0.54-0.60) for all-cause mortality; and 0.63 (95% CI 0.53-0.75) for AMI. In contrast, the incidence of ischaemic stroke, intracerebral haemorrhage and HF increased with HRs of 1.43 (95% CI 1.17-1.75), 1.30 (95% CI 1.01-1.68) and 1.84 (95% CI 1.47-2.30), respectively. During the period, rates of obesity increased from 1.04% to 2.61%, whilst CRF scores decreased slightly. Adjustment for these factors influenced these secular trends only moderately. CONCLUSION: Secular trends of young-onset CVD events demonstrated a marked shift from AMI and CVD mortality to HF and stroke incidence. Trends were significantly, though moderately, influenced by changing baseline BMI and CRF.
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Åberg et al. (2021) conducted a cohort in Cardiovascular disease (n=1,258,432). Later conscription cohort (1991-1995) vs. Earlier conscription cohort (1971-1975) was evaluated on 21-year CVD event rates (HR 0.50 (for CVD mortality), 95% CI 0.42-0.59). Compared to 1971-1975, the 1991-1995 cohort of young men had decreased 21-year CVD mortality (HR 0.50; 95% CI 0.42-0.59) but increased heart failure (HR 1.84; 95% CI 1.47-2.30) and stroke incidence.
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