March 17, 2004QJM157 citationsOpen Access
View Full PaperDo we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein
Key Result
Heart fatty-acid-binding protein (H-FABP) is a promising early marker for detecting acute myocardial infarction, appearing in blood as early as 1.5 hours after symptom onset.
Structured PICO
Does heart fatty-acid-binding protein (H-FABP) have clinical value as a marker of myocyte necrosis in acute coronary syndromes?
P
Population
Patients with acute coronary syndromes / acute myocardial infarction
I
Intervention
Heart fatty-acid-binding protein (H-FABP) as a biomarker
O
Outcome
Detection of acute myocardial infarction (AMI)surrogate
H-FABP is a promising early biomarker for acute myocardial infarction, appearing in the blood within 1.5 hours of symptom onset.
Abstract
Heart fatty-acid-binding protein (FABP) is a small cytosolic protein that is abundant in the heart and has low concentrations in the blood and in tissues outside the heart. It appears in the blood as early as 1.5 h after onset of symptoms of infarction, peaks around 6 h and returns to baseline values in 24 h. These features of H-FABP make it an excellent potential candidate for the detection of acute myocardial infarction (AMI). We review the strengths and weaknesses of H-FABP as a clinically applicable marker of myocyte necrosis in the context of acute coronary syndromes.
Cite This Study
Al-Hadi et al. (Wed,) conducted a review in Acute myocardial infarction / acute coronary syndromes. Heart fatty-acid-binding protein (H-FABP) was evaluated. Heart fatty-acid-binding protein (H-FABP) is a promising early marker for detecting acute myocardial infarction, appearing in blood as early as 1.5 hours after symptom onset.