Key result
H-FABP evaluated for diagnostic sensitivity and specificity in suspected acute myocardial infarction.
Why the study?
Acute myocardial infarction is a major cause of morbidity and death, requiring evaluation of the diagnostic efficiency, specificity, and sensitivity of biomarkers such as H-FABP.
Does H-FABP measurement accurately diagnose acute myocardial infarction in suspected AMI subjects?
Observational (n=50)
Does H-FABP measurement accurately diagnose acute myocardial infarction in suspected AMI subjects?
Answers are grounded in this paper and cite their sources.
This study evaluates the diagnostic utility of H-FABP as an early biomarker for acute myocardial infarction.
Acute myocardial infarction (AMI) is the most recurrent heart emergency which can lead to morbidity and death. During infarction, the heart releases cytoplasmic protein in the blood. These proteins such as creatine kinase, troponin and Heart type fatty acid binding protein (H-FABP) are used as indicators to spot cardiovascular arrest. This research paper aims to evaluate the efficiency, specificity and sensitivity of biomarkers in determining the AMI. This paper shows the use of direct sandwich ELISA technique to determine the level of H-FABP released in early stage of AMI. 50 suspected AMI subjects were used to observe the specificity, sensitivity and diagnostic efficacy. The study also discusses the correlation of the concentration of H-FABP in confirmed AMI, non AMI and normal subjects.
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Atindra et al. (2022) conducted an observational in Acute Myocardial Infarction (n=50). Heart type fatty acid binding protein (H-FABP) was evaluated on Specificity, sensitivity and diagnostic efficacy of H-FABP. Heart-type fatty acid binding protein (H-FABP) was evaluated for its specificity, sensitivity, and diagnostic efficacy as a biomarker in 50 subjects with suspected acute myocardial infarction.
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