January 1, 1997American Journal of Nephrology
Antihypertensive and Anti-Albuminuric Effects of Losartan Potassium and Felodipine in Chinese Elderly Hypertensive Patients with or without IMon-lnsulin-Dependent Diabetes mellitus
Key result
Losartan reduced 24-hour urinary albumin excretion by 27% compared to no change with felodipine (p=0.03) in Chinese elderly hypertensive patients, despite similar blood pressure reductions.
Why the study?
Does losartan potassium improve albuminuria compared to felodipine in elderly Chinese hypertensive patients?
Population
29 Chinese elderly hypertensive patients, including 12 with coexisting non-insulin-dependent diabetes mellitus
Comparison
Losartan potassium for 12 weeks vs Felodipine for 12 weeks
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
Discussion
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Implication
Losartan may be preferred over felodipine for albuminuria reduction in elderly hypertensives; confirms BP-independent effects of ARBs in this population.
Study Design
Type
RCT (n=29)
Blinding
double-blind
Randomization
randomized
Structured PICO
Does losartan potassium improve albuminuria compared to felodipine in elderly Chinese hypertensive patients?
P
Population
29 Chinese elderly hypertensive patients, including 12 with coexisting non-insulin-dependent diabetes mellitus
I
Intervention
Losartan potassium for 12 weeks
C
Comparator
Felodipine for 12 weeks
O
Outcome
Mean arterial pressure and 24-hour urinary albumin excretion at 12 weekssurrogate
Main Result
Absolute Event Rate: 27% vs 0%
p-value: p=0.03
Losartan provides greater reduction in albuminuria than felodipine for comparable blood pressure reductions in elderly Chinese hypertensive patients.
Limitations
- Long-term studies are required to examine whether these antiproteinuric effects of losartan can be translated to renoprotection
Cite This Study
Chan et al. (1997) conducted an RCT in Hypertension with or without non-insulin-dependent diabetes mellitus (n=29). losartan potassium vs. felodipine was evaluated on 24-hour urinary albumin excretion reduction (p=0.03). Losartan reduced 24-hour urinary albumin excretion by 27% compared to no change with felodipine (p=0.03) in Chinese elderly hypertensive patients, despite similar blood pressure reductions.