January 8, 2021Scientific ReportsOpen Access

Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Systemic lupus erythematosus (n=957). Intervention: Ang2 gene polymorphisms (rs12674822 TT genotype) vs. Healthy controls. Primary outcome: SLE susceptibility (rs12674822 TT genotype vs GG) (OR 0.564, 95% CI 0.358-0.890, p=0.014).

Q: What does this research mean for the field?

Serum Angiopoietin-2 (Ang2) levels are significantly elevated in systemic lupus erythematosus (SLE) patients, and specific Ang2 gene polymorphisms are associated with SLE susceptibility and clinical manifestations such as hematuria and proteinuria. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

The Ang2 rs12674822 TT genotype is linked to ~44% lower SLE susceptibility.

OR 0.564
95% CI 0.358-0.890
P=0.014
n=957

Why the study?

The association between serum Angiopoietin2 levels, Ang2 gene polymorphisms, and systemic lupus erythematosus susceptibility required evaluation.

Are serum Ang2 levels and Ang2 gene polymorphisms associated with systemic lupus erythematosus susceptibility?

Population

235 SLE patients, 342 other inflammatory autoimmune diseases patients, and 380 healthy individuals

Comparison

SLE patients vs other inflammatory autoimmune diseases patients vs healthy controls

Design

Case-control study

Authors

JWJiamin WangWeifang Medical University WXWang‐Dong XuSouthwest Medical University ZYZhi‐Chao Yuan

Discussion

Member takes

Implication

Ang2 elevation may aid SLE biomarker research; leaves open causal role of polymorphisms pending prospective studies.

Study Design

Type

Case-Control (n=957)

Multicenter

Yes

Structured PICO

Are serum Ang2 levels and Ang2 gene polymorphisms associated with systemic lupus erythematosus susceptibility?

Population

235 patients with systemic lupus erythematosus (SLE), 342 patients with other inflammatory autoimmune diseases, and 380 healthy individuals

Comparator

Healthy controls and patients with other inflammatory autoimmune diseases

Outcome

Association between serum Angiopoietin2 (Ang2) levels, Ang2 gene polymorphisms and systemic lupus erythematosus (SLE) susceptibilitysurrogate

Main Result

Effect estimate: OR 0.564 (95% CI 0.358-0.890)

Absolute Event Rate: 21.3% vs 36.3%

p-value: p=0.014

Serum Ang2 levels are elevated in SLE patients and specific Ang2 gene polymorphisms are associated with SLE susceptibility and clinical manifestations.

Limitations

The rs12674822 polymorphism in the control group did not conform to Hardy-Weinberg equilibrium.
The sample size is relatively limited and only includes patients from two hospitals.
The study did not explore the interaction between gene polymorphisms and environmental factors.

Cite This Study

Wang et al. (2021) conducted a case-control in Systemic lupus erythematosus (n=957). Ang2 gene polymorphisms (rs12674822 TT genotype) vs. Healthy controls was evaluated on SLE susceptibility (rs12674822 TT genotype vs GG) (OR 0.564, 95% CI 0.358-0.890, p=0.014). Serum Ang2 levels were significantly elevated in SLE patients, and Ang2 gene polymorphisms, including the rs12674822 TT genotype (OR 0.564), were negatively correlated with SLE susceptibility.

synapsesocial.com/papers/6a158db3cb801b7f954ea489 https://doi.org/10.1038/s41598-020-79544-z

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January 8, 2021Scientific ReportsOpen Access

Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients

View Full Paper

Ask AI

Bookmark

Key result

The Ang2 rs12674822 TT genotype is linked to ~44% lower SLE susceptibility.

OR 0.564
95% CI 0.358-0.890
P=0.014
n=957

Why the study?

The association between serum Angiopoietin2 levels, Ang2 gene polymorphisms, and systemic lupus erythematosus susceptibility required evaluation.

Are serum Ang2 levels and Ang2 gene polymorphisms associated with systemic lupus erythematosus susceptibility?

Population

235 SLE patients, 342 other inflammatory autoimmune diseases patients, and 380 healthy individuals

Comparison

SLE patients vs other inflammatory autoimmune diseases patients vs healthy controls

Design

Case-control study

Authors

JWJiamin WangWeifang Medical University WXWang‐Dong XuSouthwest Medical University ZYZhi‐Chao Yuan

Discussion

Member takes

Implication

Ang2 elevation may aid SLE biomarker research; leaves open causal role of polymorphisms pending prospective studies.

Study Design

Type

Case-Control (n=957)

Multicenter

Yes

Structured PICO

Are serum Ang2 levels and Ang2 gene polymorphisms associated with systemic lupus erythematosus susceptibility?

Population

235 patients with systemic lupus erythematosus (SLE), 342 patients with other inflammatory autoimmune diseases, and 380 healthy individuals

Comparator

Healthy controls and patients with other inflammatory autoimmune diseases

Outcome

Association between serum Angiopoietin2 (Ang2) levels, Ang2 gene polymorphisms and systemic lupus erythematosus (SLE) susceptibilitysurrogate

Main Result

Effect estimate: OR 0.564 (95% CI 0.358-0.890)

Absolute Event Rate: 21.3% vs 36.3%

p-value: p=0.014

Serum Ang2 levels are elevated in SLE patients and specific Ang2 gene polymorphisms are associated with SLE susceptibility and clinical manifestations.

Limitations

The rs12674822 polymorphism in the control group did not conform to Hardy-Weinberg equilibrium.
The sample size is relatively limited and only includes patients from two hospitals.
The study did not explore the interaction between gene polymorphisms and environmental factors.

Cite This Study

synapsesocial.com/papers/6a158db3cb801b7f954ea489 https://doi.org/10.1038/s41598-020-79544-z

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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