Key result
Elevated Angiopoietin-2 levels in SLE are linked to lupus nephritis and greater disease activity.
Why the study?
Angiopoietin-2 may have significant roles in the pathogenesis of glomerular diseases, but its correlation with disease activity and endothelial dysfunction in SLE patients was unclear.
Does serum Angiopoietin-2 level correlate with disease activity, endothelial dysfunction, and renal involvement in patients with systemic lupus erythematosus?
Population
81 subjects including 60 SLE patients (24 without LN, 36 with LN) and 21 healthy controls
Comparison
SLE patients with LN vs without LN and healthy controls
Design
Case-control study
Authors
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Should not yet change SLE management; hypothesis-generating for angiopoietin-2 as lupus nephritis biomarker.
Case-Control (n=81)
Does serum Angiopoietin-2 level correlate with disease activity, endothelial dysfunction, and renal involvement in patients with systemic lupus erythematosus?
Angiopoietin-2 may serve as a biomarker for endothelial activation, disease activity, and renal involvement in patients with systemic lupus erythematosus.
El-Banawy et al. (2011) conducted a case-control in Systemic lupus erythematosus (n=81). Angiopoietin-2 (ang-2) vs. Healthy controls and SLE patients without lupus nephritis was evaluated on Angiopoietin-2 level and its correlation with disease activity and endothelial dysfunction. Angiopoietin-2 levels were significantly increased in SLE patients compared to controls, and higher in patients with lupus nephritis, correlating positively with disease activity.
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