Key result
Serum Ang-2 is elevated in SLE versus controls, with highest levels in lupus nephritis.
Why the study?
Is serum Ang-2 elevated in patients with SLE and lupus nephritis compared to healthy controls?
Population
52 individuals: 30 patients with systemic lupus erythematosus and 22 healthy controls of matched age and sex.
Comparison
Serum Angiopoietin-2 (Ang-2) measurement vs Healthy controls
Design
Case-control
Authors
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Elevated Ang-2 was associated with SLE and nephritis; hypothesis-generating for biomarker use but requires prospective validation.
Observational (n=52)
Is serum Ang-2 elevated in patients with SLE and lupus nephritis compared to healthy controls?
p-value: p=<0.001
Serum Ang-2 is significantly elevated in SLE patients, particularly those with lupus nephritis, suggesting its potential as a biomarker for renal involvement.
Sawy et al. (2015) conducted an observational in Systemic lupus erythematosus (SLE) (n=52). Serum Angiopoietin-2 (Ang-2) levels vs. Healthy controls was evaluated on Serum Ang-2 concentration (p=<0.001). Serum Ang-2 concentration was significantly increased in patients with SLE compared to controls (P<0.001), with higher levels in those with lupus nephritis.
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