Noninflammatory degeneration of the artery to the sino-atrial node may contribute to the pathogenesis of cardiac arrhythmias in progressive muscular dystrophy.
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May implicate SA nodal artery degeneration in muscular dystrophy arrhythmias; hypothesis-generating case report requiring validation.
This paper describes the case of a young man with progressive muscular dystrophy who had supraventricular arrhythmias and intractable congestive failure. Hemodynamic studies and left cineventriculographic findings were compatible with a diagnosis of severe left ventricular failure. Coronary cinearteriography showed an abrupt ending of the artery to the sino-atrial node. At necropsy, a noninflammatory degeneration was found in this particular vessel. The pathogenesis of the cardiac arrhythmias seen in this condition is discussed in the light of these cineangiographic and histopathologic observations.
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Demany et al. (1969) studied this question.
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