Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1987The Journal of General PhysiologyOpen Access

Passive properties and membrane currents of canine ventricular myocytes.

View Full Paper
Ask AI
Bookmark
Share

Population

Single canine ventricular myocytes

Comparison

Measurement of membrane potential and membrane… vs Multicellular dog ventricular tissue and…

Design

Preclinical

Authors

GTGea‐Ny TsengVirginia Commonwealth UniversityRRRichard B. RobinsonColumbia UniversityBHBrian F. HoffmanBrunswick (United States)

Discussion

Loading...

Member takes

Overview

Validates isolated canine myocytes for repolarization studies; leaves open translation of transient and delayed rectifier currents to human disease.

Key Points

  • The research aims to explore the passive membrane properties and ionic currents in canine ventricular myocytes.
  • Used single microelectrodes or suction pipettes to study membrane potential and currents.
  • Analyzed different ionic currents to assess their role in action potential configuration.
  • Examined the relationship between maximum upstroke velocity of phase 0 and membrane potential.
  • Inward rectifier current significantly influences resting membrane potential and repolarization.
  • Approximately half of the myocytes exhibited a transient outward current with two distinct components.
  • Delayed rectifier current was found to contribute to repolarization, with a steeper relationship observed in myocytes compared to Purkinje fibers.

Structured PICO

P
Population
Single canine ventricular myocytes
I
Intervention
Measurement of membrane potential and membrane currents using single microelectrodes or suction pipettes
C
Comparator
Multicellular dog ventricular tissue and Purkinje fibers (reference)
O
Outcome
Membrane potential and membrane currents (passive properties and action potential configuration)surrogate

Single canine ventricular myocytes exhibit membrane properties and currents similar to multicellular tissue, but with distinct transient outward and delayed rectifier currents.

Cite This Study

Tseng et al. (1987) studied this question.

synapsesocial.com/papers/6a15922f37103a43379fed65https://doi.org/10.1085/jgp.90.5.671
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation and characterization of single canine cardiac purkinje cells.1983 · 58 citations
  2. 2THE POTASSIUM CURRENT UNDERLYING DELAYED RECTIFICATION IN CAT VENTRICULAR MUSCLE1978 · 133 citations
  3. 3Passive membrane properties of isolated feline ventricular myocytes1985 · 9 citations
  4. 4Durations of Transmembrane Action Potentials and Functional Refractory Periods of Canine False Tendon and Ventricular Myocardium:1965 · 105 citations
  5. 5Transient outward current carried by potassium and sodium in quiescent atrioventricular node cells of rabbits.1985 · 98 citations