What does this research mean for the field?

Left atrial enlargement is associated with a significantly increased risk of ischemic stroke in patients with nonvalvular atrial fibrillation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether left atrial size is associated with the occurrence of ischemic stroke in patients with nonvalvular atrial fibrillation.

February 1, 1986Annals of Neurology

Atrial size, atrial fibrillation, and stroke

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Why the study?

Is left atrial enlargement associated with an increased risk of ischemic stroke in patients with atrial fibrillation?

Population

n=40 patients with atrial fibrillation and no known valvular disease, comprising 20 patients with ischemic…

Design

Case-control, Echocardiograms were analyzed without knowledge of patient…

Authors

LCLouis R. CaplanUniversity of Arkansas at Little Rock IDI A D'CruzVeterans Health Administration DHDaniel B. HierMissouri University of Science and Technology

Discussion

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Implication

LA enlargement may mark higher stroke risk in AF; leaves open incremental value for stratification in prospective studies.

Key Points

To determine whether left atrial size is associated with the occurrence of ischemic stroke in patients with nonvalvular atrial fibrillation.
Retrospectively reviewed M-mode and two-dimensional echocardiographic images in 40 patients with atrial fibrillation: 20 with ischemic stroke and no known valvular disease, and 20 without known stroke.
Measured and analyzed left atrial dimensions while blinded to patient group assignment.
Two-dimensional echocardiography revealed left atrial enlargement in 90% of patients with stroke compared with 20% of patients without stroke.
Left atrial enlargement is strongly associated with ischemic stroke risk in individuals with atrial fibrillation.

Structured PICO

Is left atrial enlargement associated with an increased risk of ischemic stroke in patients with atrial fibrillation?

Population

n=40 patients with atrial fibrillation and no known valvular disease, comprising 20 patients with ischemic stroke and 20 patients without known stroke.

Outcome

Left atrial size and presence of left atrial enlargement measured by M-mode and two-dimensional echocardiographysurrogate

Left atrial enlargement is significantly more prevalent in atrial fibrillation patients who have suffered an ischemic stroke, suggesting it may serve as a marker for additional stroke risk.

Cite This Study

Caplan et al. (1986) studied this question.

synapsesocial.com/papers/6a1592459b87f33fc69fac0b https://doi.org/10.1002/ana.410190208

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF Echocardiography Valvular heart disease

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Atrial size, atrial fibrillation, and stroke

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Atrial size, atrial fibrillation, and stroke

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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