What is the clinical evidence from this study?

Study design: Cohort. Population: Chronic heart failure (n=124). Intervention: Duke Activity Status Index (DASI) score ≤ 23 vs. DASI score > 23. Primary outcome: All-cause mortality (HR 4.71, p=<0.001).

What does this research mean for the field?

A Duke Activity Status Index (DASI) score of ≤23 points is a strong predictor of 36-month mortality in patients with chronic heart failure, associated with a significantly higher mortality rate compared to scores >23. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 2024BMC Cardiovascular DisordersOpen Access

Prognostic value of the duke activity Status Index Questionnaire in predicting mortality in patients with chronic heart failure: 36-month follow-up study

Q: What are the key findings of this study?

A Duke Activity Status Index score of ≤23 points was associated with a significantly higher 36-month mortality rate compared to a score >23 points (43% vs 11%, HR 4.71) in patients with chronic heart failure.

Q: What does this research mean for the field?

A Duke Activity Status Index (DASI) score of ≤23 points is a strong predictor of 36-month mortality in patients with chronic heart failure, associated with a significantly higher mortality rate compared to scores >23. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Low DASI score linked to ~371% higher mortality in chronic heart failure.

HR 4.71
P<0.001
n=124

Why the study?

Studies exploring optimal Duke Activity Status Index (DASI) questionnaire threshold scores for predicting mortality in chronic heart failure are limited.

Does a Duke Activity Status Index (DASI) questionnaire score ≤23 predict mortality in patients with chronic heart failure?

Comparison

DASI score <=23 vs >23 points

Design

Prospective cohort study

Follow-up

36-month

Authors

ASAldair Darlan Santos‐de‐AraújoUniversidade Federal de São Carlos DBDaniela Bassi‐DibaiUniversidade Federal de São Carlos IDIzadora Moraes DouradoUniversidade Federal de São Carlos

Discussion

Member takes

Implication

May support DASI ≤23 for mortality risk stratification in chronic HF; hypothesis-generating, requires prospective validation before practice change.

Study Design

Type

Cohort (n=124)

Multicenter

Structured PICO

Does a Duke Activity Status Index (DASI) questionnaire score ≤23 predict mortality in patients with chronic heart failure?

Population

124 patients with chronic heart failure (LVEF <50%), mean age 62 years, 69% male, from Brazil. Key inclusion: >40 years old, diagnosed with CHF, LVEF <50%, clinically stable without medication changes in last 3 months. Key exclusion: >80 years old, HFpEF, recent cardiac events within 6 months, decompensation within 3 months, implantable pacemaker.

Intervention

Duke Activity Status Index (DASI) questionnaire score ≤23 points

Comparator

Duke Activity Status Index (DASI) questionnaire score >23 points

Outcome

All-cause mortality over 36-month follow-uphard clinical

Main Result

Effect estimate: HR 4.71

Absolute Event Rate: 43% vs 11%

p-value: p=<0.001

A Duke Activity Status Index (DASI) score of ≤23 is a strong, independent predictor of 36-month mortality in patients with chronic heart failure and reduced ejection fraction.

Limitations

Participants who chose to leave the study also chose to withdraw from the follow-up, and it was therefore not possible to censor them.
Patients with CHF and preserved ejection fraction were not included, so findings may not translate to that phenotype.
The Youden Index for the DASI cutoff has a limited value (0.40).

Cite This Study

Santos‐de‐Araújo et al. (2024) conducted a cohort in Chronic heart failure (n=124). Duke Activity Status Index (DASI) score ≤ 23 vs. DASI score > 23 was evaluated on All-cause mortality (HR 4.71, p=<0.001). A Duke Activity Status Index score of ≤23 points was associated with a significantly higher 36-month mortality rate compared to a score >23 points (43% vs 11%, HR 4.71) in patients with chronic heart failure.

synapsesocial.com/papers/6a1597dfd73ae7522a4e352c https://doi.org/10.1186/s12872-024-04218-x

Topics

Heart failure HFrEF treatment

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Implication

May support DASI ≤23 for mortality risk stratification in chronic HF; hypothesis-generating, requires prospective validation before practice change.

Prognostic value of the duke activity Status Index Questionnaire in predicting mortality in patients with chronic heart failure: 36-month follow-up study

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Prognostic value of the duke activity Status Index Questionnaire in predicting mortality in patients with chronic heart failure: 36-month follow-up study

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider