What does this research mean for the field?

Bariatric surgery improves insulin sensitivity within one week independent of caloric intake, with Roux-en-Y gastric bypass producing more pronounced metabolic effects than laparoscopic adjustable gastric banding. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 29, 2016Diabetes CareOpen Access

Short-term Effects of Laparoscopic Adjustable Gastric Banding Versus Roux-en-Y Gastric Bypass

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Nondiabetic obesity (n=20). Intervention: Laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) vs. Very low caloric intake (VLCI). Primary outcome: Insulin sensitivity (IS) and insulin secretion (ISR).

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Key result

Bariatric surgery improved insulin sensitivity within 1 week independent of caloric intake, with RYGB and LAGB leading to 5.5 kg and 5.2 kg weight loss vs 2.1 kg with very low caloric intake alone.

Why the study?

Does bariatric surgery (LAGB or RYGB) improve insulin sensitivity independently of caloric restriction in nondiabetic obese subjects?

Population

20 nondiabetic obese subjects

Comparison

Bariatric surgery evaluated 1 week post-surgery… vs Very low caloric intake alone for 1 week prior…

Design

Cohort

Follow-up

1 week post-surgery

Authors

AGAmalia GastaldelliPreventive Cardiology AIAmerigo IaconelliAgostino Gemelli University Polyclinic MGMelania GagginiIstituto di Fisiologia Clinica

Discussion

Member takes

Implication

Bariatric surgery may improve early insulin sensitivity beyond caloric restriction in nondiabetic obesity; leaves open confirmation in randomized trials.

Study Design

Type

Cohort (n=20)

Structured PICO

Does bariatric surgery (LAGB or RYGB) improve insulin sensitivity independently of caloric restriction in nondiabetic obese subjects?

Population

20 nondiabetic obese subjects (n=10 for laparoscopic adjustable gastric banding, n=10 for Roux-en-Y gastric bypass)

Intervention

Bariatric surgery (laparoscopic adjustable gastric banding [LAGB] or Roux-en-Y gastric bypass [RYGB]) evaluated 1 week post-surgery under a very low caloric intake regimen (600 kcal/day)

Comparator

Very low caloric intake (VLCI, 600 kcal/day) alone for 1 week prior to surgery

Outcome

Insulin sensitivity (peripheral, hepatic, and adipose) and insulin secretion (ISR) at 1 weeksurrogate

Bariatric surgery, particularly Roux-en-Y gastric bypass, improves insulin sensitivity within 1 week independently of caloric restriction in nondiabetic obese subjects.

Cite This Study

Gastaldelli et al. (2016) conducted a cohort in Nondiabetic obesity (n=20). Laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) vs. Very low caloric intake (VLCI) was evaluated on Insulin sensitivity (IS) and insulin secretion (ISR). Bariatric surgery improved insulin sensitivity within 1 week independent of caloric intake, with RYGB and LAGB leading to 5.5 kg and 5.2 kg weight loss vs 2.1 kg with very low caloric intake alone.

synapsesocial.com/papers/6a15987979ff98d0de4edd45 https://doi.org/10.2337/dc15-2823

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August 29, 2016Diabetes CareOpen Access

Short-term Effects of Laparoscopic Adjustable Gastric Banding Versus Roux-en-Y Gastric Bypass

View Full Paper

Ask AI

Bookmark

Key result

Bariatric surgery improved insulin sensitivity within 1 week independent of caloric intake, with RYGB and LAGB leading to 5.5 kg and 5.2 kg weight loss vs 2.1 kg with very low caloric intake alone.

Why the study?

Does bariatric surgery (LAGB or RYGB) improve insulin sensitivity independently of caloric restriction in nondiabetic obese subjects?

Population

20 nondiabetic obese subjects

Comparison

Bariatric surgery evaluated 1 week post-surgery… vs Very low caloric intake alone for 1 week prior…

Design

Cohort

Follow-up

1 week post-surgery

Authors

AGAmalia GastaldelliPreventive Cardiology AIAmerigo IaconelliAgostino Gemelli University Polyclinic MGMelania GagginiIstituto di Fisiologia Clinica

Discussion

Member takes

Implication

Bariatric surgery may improve early insulin sensitivity beyond caloric restriction in nondiabetic obesity; leaves open confirmation in randomized trials.

Study Design

Type

Cohort (n=20)

Structured PICO

Does bariatric surgery (LAGB or RYGB) improve insulin sensitivity independently of caloric restriction in nondiabetic obese subjects?

Population

20 nondiabetic obese subjects (n=10 for laparoscopic adjustable gastric banding, n=10 for Roux-en-Y gastric bypass)

Intervention

Bariatric surgery (laparoscopic adjustable gastric banding [LAGB] or Roux-en-Y gastric bypass [RYGB]) evaluated 1 week post-surgery under a very low caloric intake regimen (600 kcal/day)

Comparator

Very low caloric intake (VLCI, 600 kcal/day) alone for 1 week prior to surgery

Outcome

Insulin sensitivity (peripheral, hepatic, and adipose) and insulin secretion (ISR) at 1 weeksurrogate

Bariatric surgery, particularly Roux-en-Y gastric bypass, improves insulin sensitivity within 1 week independently of caloric restriction in nondiabetic obese subjects.

Cite This Study

synapsesocial.com/papers/6a15987979ff98d0de4edd45 https://doi.org/10.2337/dc15-2823

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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