Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study)
Key result
Each 5-mm Hg increase in systolic blood pressure was linearly associated with an 8-μm increase in carotid intima-media thickness (β=8.249; 95% CI 2.490-14.008; P=0.005).
Why the study?
Is systolic blood pressure linearly associated with carotid intima-media thickness in adults with and without hypertension?
Population
696 adult participants from the STANISLAS cohort
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports linear SBP-cIMT link independent of hypertension; extends observational data but leaves causal effects on atherosclerosis open.
Study Design
Type
Cross-Sectional (n=696)
Multicenter
No
Structured PICO
Is systolic blood pressure linearly associated with carotid intima-media thickness in adults with and without hypertension?
P
Population
696 adult participants from the STANISLAS cohort (a familial longitudinal cohort from the Nancy region of France)
I
Intervention
Higher systolic blood pressure (measured via ambulatory BP monitoring)
O
Outcome
Carotid intima-media thickness (cIMT) >900 μm and continuous cIMTsurrogate
Main Result
Effect estimate: β=8.249 (95% CI 2.490-14.008)
p-value: p=0.005
Systolic blood pressure is linearly and continuously associated with higher carotid intima-media thickness even prior to overt hypertension.
Cite This Study
Ferreira et al. (2016) conducted a cross-sectional in Cardiovascular risk (n=696). Systolic blood pressure was evaluated on Carotid intima-media thickness (cIMT) (β=8.249, 95% CI 2.490-14.008, p=0.005). Each 5-mm Hg increase in systolic blood pressure was linearly associated with an 8-μm increase in carotid intima-media thickness (β=8.249; 95% CI 2.490-14.008; P=0.005).