Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2017Circulation Arrhythmia and ElectrophysiologyOpen Access

Targets and End Points in Cardiac Autonomic Denervation Procedures

View Full Paper
Ask AI
Bookmark
Share

Key result

Radiofrequency ablation targeting the interatrial septum increased heart rate by 23.8% and significantly shortened Wenckebach cycle length (P=0.0009) and AH interval (P=0.0014).

Why the study?

Does radiofrequency ablation of ganglionated plexuses improve heart rate and atrioventricular nodal conduction in patients with symptomatic bradycardia?

Population

14 patients with cardioinhibitory syncope, advanced atrioventricular block or sinus arrest, and no…

Comparison

Anatomic mapping of ganglionated plexuses… vs Baseline (before ablation)

Design

Case_series

Follow-up

Immediate (during procedure)

Authors

EREsteban Wisnivesky Rocca RivarolaDHDenise HachulTWTan Chen Wu

Discussion

Loading...

Member takes

Overview

May improve heart rate and AV conduction in bradycardia; hypothesis-generating, should not yet change practice.

Study Design

Type

Observational (n=14)

Structured PICO

Does radiofrequency ablation of ganglionated plexuses improve heart rate and atrioventricular nodal conduction in patients with symptomatic bradycardia?

P
Population
14 patients with cardioinhibitory syncope, advanced atrioventricular block or sinus arrest, and no structural heart disease (mean age 34.0±13.8 years, 50% men).
I
Intervention
Anatomic mapping of ganglionated plexuses followed by radiofrequency ablation.
C
Comparator
Baseline (before ablation)
O
Outcome
Changes in heart rate, sinus node recovery time, Wenckebach cycle length, and atrial-His (AH) interval before and after every radiofrequency pulse.surrogate

Main Result

p-value: p=0.0009

Targeting specific sites of the interatrial septum during cardiac autonomic denervation significantly improves heart rate and AV nodal conduction properties in patients with symptomatic bradycardia.

Cite This Study

Rivarola et al. (2017) conducted an observational in Symptomatic bradycardia (cardioinhibitory syncope, advanced atrioventricular block or sinus arrest) (n=14). Radiofrequency ablation of ganglionated plexuses vs. Baseline (before ablation) was evaluated on R-R interval, Wenckebach cycle length, and atrial-His (AH) interval (p=0.0009). Radiofrequency ablation targeting the interatrial septum increased heart rate by 23.8% and significantly shortened Wenckebach cycle length (P=0.0009) and AH interval (P=0.0014).

synapsesocial.com/papers/6a15b80b814bf8ec9a4ef707https://doi.org/10.1161/circep.116.004638
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Atrial Vagal Denervation Guided by Evoked Vagal Reflex to Treat Patients With Paroxysmal Atrial Fibrillation2006 · 285 citations
  2. 2Selective Vagal Denervation of the Sinus and Atrioventricular Nodes, Guided by Vagal Reflexes Induced by High Frequency Stimulation, to Treat Refractory Neurally Mediated Syncope2008 · 50 citations
  3. 3“Cardioneuroablation” – new treatment for neurocardiogenic syncope, functional AV block and sinus dysfunction using catheter RF-ablation2005 · 353 citations
  4. 4Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation2004 · 1,023 citations
  5. 5Characterization of the Left Atrial Neural Network and its Impact on Autonomic Modification Procedures2013 · 58 citations