Key result
Oestrogens drive sexually dimorphic adipose tissue distribution and function, influencing metabolic syndrome risk.
Why the study?
Oestrogens determine adipose tissue distribution, function, and health, and contribute to sexually dimorphic fat distribution and the development of metabolic syndrome and other chronic conditions.
Answers are grounded in this paper and cite their sources.
This review highlights the crucial evolutionary and physiological roles of oestrogens in regulating adipose tissue distribution and metabolic health.
Oestrogens are sex steroid hormones that have gained prominence over the years owing to their crucial roles in human health and reproduction functions which have been preserved throughout evolution. One of oestrogens actions, and the focus of this review, is their ability to determine adipose tissue distribution, function and adipose tissue 'health'. Body fat distribution is sexually dimorphic, affecting males and females differently. These differences are also apparent in the development of the metabolic syndrome and other chronic conditions where oestrogens are critical. In this review, we summarize the different molecular mechanisms, pathways and resulting pathophysiology which are a result of oestrogens actions in and on adipose tissues. This article is part of a discussion meeting issue 'Causes of obesity: theories, conjectures and evidence (Part I)'.
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Bardhi et al. (2023) conducted a review in Adipose tissue distribution and metabolic syndrome. Oestrogens was evaluated. Oestrogens critically determine sexually dimorphic adipose tissue distribution and function, influencing the development of metabolic syndrome and other chronic conditions.
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