Key result
Brugada syndrome in Japan has an incidence of 0.1% to 0.2% in the general population, presenting with lower rates of SCN5A mutations and family history of sudden cardiac death than other countries.
This review highlights that while Brugada syndrome is more prevalent in Japan, its genetic and clinical risk profiles differ from Western populations, necessitating tailored risk stratification.
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May warrant ethnicity-specific risk stratification in Brugada syndrome; leaves open prospective validation of genetic differences.
The incidence of Brugada syndrome (BS) is relatively high in Japan compared with the rest of the world, ranging between 0.1% and 0.2% in the general population. BS in Japan, as in other countries, is most prevalent in middle-aged men, and has characteristics ECG changes, a high recurrence rate in symptomatic patients, and relatively low incidence of SCN5A mutations. In contrast, both the incidence of a family history of BS and/or sudden cardiac death and the rate of developing cardiac events in asymptomatic patients are less in Japan than in other countries. Increased vagal tone and/or decreased sympathetic activity are suggested as provoking cardiac events. Several factors should be evaluated in risk stratification for recurrence of life-threatening arrhythmias, because there appears to be no single determinant for risk stratification: spontaneous ST elevation of coved-type (Type 1), family history of sudden cardiac death, inducible ventricular tachycardia/ventricular fibrillation and positive late potentials. An implantable cardioverter defibrillator is recommended for patients with aborted sudden cardiac death.
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Masayasu Hiraoka (2007) conducted a review in Brugada syndrome. Brugada syndrome in Japan has an incidence of 0.1% to 0.2% in the general population, presenting with lower rates of SCN5A mutations and family history of sudden cardiac death than other countries.
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