Key result
Brugada syndrome prevalence is approximately 0.15% in Asian adults compared to less than 0.02% in the West, with a higher frequency in Japanese men (94-96%) than Caucasian men (72-80%).
Brugada syndrome exhibits a significantly higher prevalence in Asia compared to the West, with a pronounced male predominance that is even stronger in Japanese patients.
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May guide ethnicity-aware diagnostic thresholds; leaves open genetic-environmental interactions in Brugada syndrome.
Brugada syndrome is an inherited disease that causes sudden death because of ventricular fibrillation. Its prevalence is approximately 0.15% in adults and 0.005% in children in Asia, and less than 0.02% in the West. The reason for the higher prevalence in Asia is likely ethnic‐specific polymorphisms modulating the activity of the primary disease‐causing mutation. In Japan, the incidence of Brugada‐pattern electrocardiogram (ECG) is 14.2 per 100,000 person‐years. Data from multicenter registries indicate that its frequency in men with Brugada syndrome is higher in Japanese patients (94–96%) than in Caucasian patients (72–80%). Healthy individuals with Brugada‐type ECG have a favorable prognosis with an annual death rate of less than 0.5%.
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Shiro Kamakura (2013) conducted a review in Brugada syndrome. Brugada syndrome was evaluated. Brugada syndrome prevalence is approximately 0.15% in Asian adults compared to less than 0.02% in the West, with a higher frequency in Japanese men (94-96%) than Caucasian men (72-80%).
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