What does this research mean for the field?

Propagated electrical excitation in the canine heart functions as an electromotive surface with a constant width of approximately 0.9 mm, where the true voltage approximates the transmembrane action potential and is significantly shunted by the surrounding lungs and thorax. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to investigate the characteristics of propagated electrical activity in the canine heart, focusing on voltage measurements.

April 1, 1970Circulation ResearchOpen Access

An Experimental Study of Propagated Electrical Activity in the Canine Heart

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Population

Canine heart model

Comparison

Measurement of cardiac electromotive surface… vs Chest closed vs. chest open; normal propagation…

Design

Preclinical

Authors

CACondon R. Vander ArkUniversity of Wisconsin–Madison ERErnest W. ReynoldsStrong Memorial Hospital

Discussion

Member takes

Implication

May artifactually elevate epicardial voltage readings with open chest; leaves open translation to human electrophysiology.

Key Points

This study aims to investigate the characteristics of propagated electrical activity in the canine heart, focusing on voltage measurements.
Measured voltage across the electromotive surface in canines with chest closed and open.
Analyzed the effect of cross-fiber activation on voltage and conduction velocity.
The mean voltage across the electromotive surface was significantly higher with the chest open (74.1 ± 8.3 mv) compared to closed (62.4 ± 7.2 mv), P < .001.
Cross-fiber activation reduced voltage by 29.5% and conduction velocity by 51.8%.
Found nine measurements exceeding 80 mv and two above 90 mv, indicating similarity to transmembrane action potential.

Structured PICO

Population

Canine heart model

Intervention

Measurement of cardiac electromotive surface voltage under different conditions (chest closed vs. chest open, cross-fiber activation)

Comparator

Chest closed vs. chest open; normal propagation vs. cross-fiber activation

Outcome

Voltage across the electromotive surface and conduction velocitysurrogate

Opening the chest significantly increases the measured voltage across the cardiac electromotive surface in a canine model, suggesting a shunting effect of the lungs and thorax.

Cite This Study

Ark et al. (1970) studied this question.

synapsesocial.com/papers/6a15f3dfcaf7e3ea0ee3e635 https://doi.org/10.1161/01.res.26.4.451

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An Experimental Study of Propagated Electrical Activity in the Canine Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

An Experimental Study of Propagated Electrical Activity in the Canine Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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