Does intra-arterial insulin increase tissue cholesterol and fatty acids in alloxan-diabetic dogs?
Local intra-arterial insulin administration increases tissue cholesterol and fatty acids in the arteries and muscles of diabetic dogs, suggesting a direct local effect of insulin on lipid deposition.
Insulin and saline were injected into the right and left femoral arteries respectively of 19 alloxan-diabetes-mellitus dogs for 1 to 28 weeks. A significant increase of artery tissue cholesterol and total fatty acids was found on comparing the insulin-administered right leg with the saline-administered left leg. Similarly, a significant increase of total fatty acids in muscle was found on comparing the right with the left leg of the alloxan-diabetes mellitus dogs. No significant differences were observed in the normal animals when the insulin-injected side was compared with the noninjected.
Cruz et al. (1961) studied this question.
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