Key result
Increased cyclic stretch and decreased shear stress drive the transition from isolated to combined PH.
Why the study?
Knowledge gaps persist regarding the mechanisms responsible for the progression of isolated postcapillary pulmonary hypertension to combined pre-/postcapillary pulmonary hypertension in left heart failure.
Design
Review
Authors
Loading...
May inform pharmacologic targeting of mechanotransduction in Cpc-PH; leaves open effects on right heart failure prevention.
Identifying biomechanical and mechanobiological mechanisms of Cpc-PH progression may highlight potential pharmacologic avenues to prevent right heart failure and subsequent mortality.
Allen et al. (2023) conducted a review in Combined pre-/postcapillary pulmonary hypertension. Pathologically increased cyclic stretch and decreased wall shear stress drive mechanotransduction and detrimental remodeling, propelling the transition from isolated to combined pulmonary hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: