Key result
Patients with combined post- and precapillary pulmonary hypertension have a baseline resistance-compliance time that is higher than in isolated postcapillary PH and lower than in PAH (P<0.001).
Why the study?
Does the resistance-compliance (RC) time in combined post- and precapillary pulmonary hypertension (Cpc-PH) resemble that of pulmonary arterial hypertension (PAH) more than isolated postcapillary PH (Ipc-PH)?
Population
282 consecutive patients with pulmonary hypertension referred for right heart catheterization with a fluid…
Comparison
Right heart catheterization with fluid challenge… vs Comparison between combined post- and…
Design
Cohort
Authors
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Intermediate RC time may aid Cpc-PH phenotyping; leaves open therapeutic implications pending validation.
Cohort (n=4,664)
Does the resistance-compliance (RC) time in combined post- and precapillary pulmonary hypertension (Cpc-PH) resemble that of pulmonary arterial hypertension (PAH) more than isolated postcapillary PH (Ipc-PH)?
p-value: p=<0.001
Patients with combined post- and precapillary pulmonary hypertension exhibit pulmonary vascular physiology (RC time) that more closely resembles pulmonary arterial hypertension than isolated postcapillary pulmonary hypertension, suggesting similar vascular remodeling.
Assad et al. (2016) conducted a cohort in Pulmonary hypertension (n=4,664). Combined postcapillary and precapillary pulmonary hypertension (Cpc-PH) vs. Isolated postcapillary PH (Ipc-PH) and pulmonary arterial hypertension (PAH) was evaluated on Resistance-compliance (RC) time (p=<0.001). Patients with combined post- and precapillary pulmonary hypertension have a baseline resistance-compliance time that is higher than in isolated postcapillary PH and lower than in PAH (P<0.001).
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