Key result
Decreased collagen content induced by oxidized glutathione increased active stiffness (5.86 vs 3.96, P<0.05) and myocyte cross-sectional area in rat papillary muscles compared to controls.
Why the study?
Does alteration in myocardial collagen content affect papillary muscle function in rats?
Population
Rat model of altered myocardial collagen content
Comparison
Alteration of myocardial collagen content vs Untreated control rats
Design
Preclinical
Follow-up
8 weeks for RHTR rats (5 weeks ischemia + 3 weeks treatment)
Authors
Loading...
Suggests collagen reduction may increase stiffness in rat myocardium; leaves open relevance to human diastolic function.
Does alteration in myocardial collagen content affect papillary muscle function in rats?
Absolute Event Rate: 5.86% vs 3.96%
p-value: p=<0.05
In a rat model, decreased myocardial collagen content is associated with myocyte hypertrophy and increased active stiffness, whereas increased collagen concentration causes diastolic dysfunction without affecting systolic function.
Matsubara et al. (2000) studied Myocardial collagen alterations (animal model). Oxidized glutathione (GSSG) or unilateral renal ischemia + ramipril (RHTR) vs. Untreated controls was evaluated on Active stiffness (AS; g. cm(-2). %L(max)(-1)) (p=<0.05). Decreased collagen content induced by oxidized glutathione increased active stiffness (5.86 vs 3.96, P<0.05) and myocyte cross-sectional area in rat papillary muscles compared to controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: