Key result
Decreased collagen content induced by oxidized glutathione increased active stiffness (5.86 vs 3.96, P<0.05) and myocyte cross-sectional area in rat papillary muscles compared to controls.
Why the study?
Does alteration in myocardial collagen content affect papillary muscle function in rats?
Does alteration in myocardial collagen content affect papillary muscle function in rats?
Absolute Event Rate: 5.86% vs 3.96%
p-value: p=<0.05
In a rat model, decreased myocardial collagen content is associated with myocyte hypertrophy and increased active stiffness, whereas increased collagen concentration causes diastolic dysfunction without affecting systolic function.
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Suggests collagen reduction may increase stiffness in rat myocardium; leaves open relevance to human diastolic function.
Matsubara et al. (2000) studied Myocardial collagen alterations (animal model). Oxidized glutathione (GSSG) or unilateral renal ischemia + ramipril (RHTR) vs. Untreated controls was evaluated on Active stiffness (AS; g. cm(-2). %L(max)(-1)) (p=<0.05). Decreased collagen content induced by oxidized glutathione increased active stiffness (5.86 vs 3.96, P<0.05) and myocyte cross-sectional area in rat papillary muscles compared to controls.
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