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December 1, 1963American Journal of Physiology-Legacy Content36 citations

Effect of pacemaker location on cardiac function in complete A-V heart block

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Why the study?

Does the location of ectopic ventricular stimulation affect ventricular performance in complete A-V heart block?

Population

6 dogs with complete A-V heart block produced by ligating the A-V bundle

Comparison

Ectopic ventricular stimulation using small… vs Comparison between stimulation sites

Design

Preclinical

Follow-up

Several days after recovery

Authors

FFFred W. FletcherETErnest O. TheilenMLMontague S. Lawrence

Discussion

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Overview

Pacing site independence in canine AV block leaves open whether location affects human ventricular performance.

Structured PICO

Does the location of ectopic ventricular stimulation affect ventricular performance in complete A-V heart block?

P
Population
6 dogs with complete A-V heart block produced by ligating the A-V bundle
I
Intervention
Ectopic ventricular stimulation using small bipolar electrodes implanted in the apex, high lateral wall, and posterior septal region at varying rates between 60 and 240 beats/min
C
Comparator
Comparison between stimulation sites (apex, high lateral wall, posterior septal region)
O
Outcome
Cardiac output (measured by dye dilution)surrogate

In a canine model of complete heart block, the location of ventricular pacing does not significantly affect cardiac output or systemic pressure.

Cite This Study

Fletcher et al. (1963) studied this question.

synapsesocial.com/papers/6a160e2a58f24b40adb56c3ehttps://doi.org/10.1152/ajplegacy.1963.205.6.1232
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