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Antiserum against heart contractile proteins causes myocardial degeneration and death in developing rat embryos.
An antiserum with specific reactivity against the contractile proteins of the rat heart has been raised in the rabbit. Fractions of the serum have been shown to enter the isolated rat embryo by electron-microscopic studies with ferritin, where they bind to the myocardium, producing degenerative changes. Both IgG and IgM fractions are toxic, producing foetal death in a large proportion of explanted embryos.
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Colin L. Berry (1971) studied this question.
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