What does this research mean for the field?

During rat heart development, cardiac troponin T switches from a fetal 42.5-kDa isoform to an adult 41-kDa isoform within the first two weeks after birth, a process that is independent of conditions known to alter cardiac myosin composition. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1988Journal of Biological ChemistryOpen Access

Troponin T switching in the developing rat heart.

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Population

Developing rat heart, including models of hypothyroidism, hypertrophy secondary to systemic hypertension…

Design

Preclinical

Authors

LSL SagginUniversity of Padua SASimonetta AusoniUniversity of Padua LGLuisa GorzaHôpital Foch

Discussion

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Implication

Rat troponin T isoform switch is thyroid-independent; leaves open human developmental or disease relevance.

Structured PICO

Population

Developing rat heart (fetal and adult ventricles), including models of hypothyroidism, hypertrophy secondary to systemic hypertension, and propylthiouracil treatment of pregnant/nursing rats.

Intervention

Immunoblot analysis using a monoclonal antibody specific for cardiac troponin T

Outcome

Troponin T isoform profile changes during developmentsurrogate

This study demonstrates a developmental switch in cardiac troponin T isoforms in rats that occurs independently of thyroid hormone status or cardiac hypertrophy.

Cite This Study

Saggin et al. (1988) studied this question.

synapsesocial.com/papers/6a1c6eef973ffece4bc3cf99 https://doi.org/10.1016/s0021-9258(19)81384-4

Topics

Hypertension management

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Troponin T switching in the developing rat heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Troponin T switching in the developing rat heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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