Key result
Hyponatremia (OR 3.6; 95% CI 1.7-7.9), respiratory rate >20 (OR 3.4), and renal dysfunction (OR 2.7) predicted 90-day death or urgent transplant in PAH patients with acute right heart failure.
Why the study?
What factors predict 90-day mortality or urgent transplantation in patients with PAH hospitalized for acute right heart failure?
Population
119 patients with pulmonary arterial hypertension hospitalized for acute right heart failure
Design
Cohort
Follow-up
90 days
Authors
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These markers may aid short-term risk stratification in PAH acute right heart failure; leaves open prospective validation before guiding care.
Cohort (n=119)
No
What factors predict 90-day mortality or urgent transplantation in patients with PAH hospitalized for acute right heart failure?
Effect estimate: OR 3.6 (95% CI 1.7-7.9)
In patients with PAH hospitalized for acute right heart failure, simple clinical markers including elevated respiratory rate, renal dysfunction, hyponatremia, and severe tricuspid regurgitation strongly predict 90-day mortality or urgent transplantation.
Haddad et al. (2011) conducted a cohort in Pulmonary Arterial Hypertension with acute right heart failure (n=119). Clinical and laboratory risk factors on admission was evaluated on 90-day mortality or urgent transplantation (OR 3.6, 95% CI 1.7-7.9). Hyponatremia (OR 3.6; 95% CI 1.7-7.9), respiratory rate >20 (OR 3.4), and renal dysfunction (OR 2.7) predicted 90-day death or urgent transplant in PAH patients with acute right heart failure.