Hospitalisation for right heart failure in PAH had a 14% in-hospital mortality rate, with connective tissue disease (OR 4.92) and systolic BP <100 mmHg (OR 4.32) as major prognostic factors.
Cohort (n=90)
Hospitalization for right heart failure in PAH is associated with high short-term mortality, with hyponatremia, hypotension, and underlying connective tissue disease serving as key prognostic factors.
The aim of this study was to examine the causes and outcomes of hospitalisation in patients with pulmonary arterial hypertension (PAH). 205 consecutive hospitalisations occurring between 2000 and 2009 in 90 PAH patients were studied. The leading causes for hospitalisation were right heart failure (RHF; 56%), infection (16%) and bleeding disorders (8%). For patients with RHF, in-hospital mortality was 14% overall, 46% for patients receiving inotropes and 48% for those admitted to the intensive care unit. The predictors for in-hospital mortality were the presence of connective tissue disease (CTD) (OR 4.92), systolic blood pressure <100 mmHg (OR 4.32) and Na ≤ 136 mEq · L(-1) (OR 4.29). Mortality after discharge was 13, 26 and 35% at 3, 6 and 12 months, respectively. World Health Organization functional class prior to admission, renal dysfunction, Charlson comorbidity index, and the presence of CTD were all predictors of mortality after discharge. Hyponatraemia and low systolic blood pressure upon admission and underlying CTD are the main prognostic factors for in-hospital mortality in patients with PAH admitted for RHF. The short-term outcomes after discharge are poor and remarkably worse in patients with underlying CTD or renal impairment. Early recognition of these factors may guide decisions regarding more aggressive therapy, including consideration for lung transplantation.
Campo et al. (Thu,) conducted a cohort in Pulmonary arterial hypertension (n=90). Hospitalisation for right heart failure was evaluated on In-hospital mortality for patients with right heart failure. Hospitalisation for right heart failure in PAH had a 14% in-hospital mortality rate, with connective tissue disease (OR 4.92) and systolic BP <100 mmHg (OR 4.32) as major prognostic factors.