Early Postrranscatheter Aortic Valve Replacement Heart Failure Hospitalization and Outcomes in Older Patients

Figures

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  Figure 1. Study cohort selection flow diagram. Flow diagram representing patients alive and free from 30‐day readmission. Patients were subsequently classified based on early post‐TAVR HF hospitalization status, as those with no HF hospitalization (31–365 days) and those with early post‐TAVR HF hospitalization. HF indicates heart failure; and TAVR, transcatheter aortic valve replacement.

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  Figure 2. Long‐term all‐cause mortality according to early post‐TAVR heart failure hospitalization using a time‐varying Cox model. One‐year mortality was 43.8% among patients with early post‐TAVR HF hospitalization compared with 3.6% among those with no HF hospitalization (31–365 days); by 5 years, mortality reached 80.6% vs 41.0%, respectively (log‐rank P value <0.001). The analysis includes patients who survived at least 30 days post‐TAVR without any HF hospitalization during that period. A time‐varying approach was used: patients initially entered the nonreadmitted group, and those who experienced HF readmission between 31 days and 1‐year post‐TAVR were reclassified into the readmission group. Survival was measured from day 30 postprocedure through 5 years of follow‐up. HF indicates heart failure; and TAVR, transcatheter aortic valve replacement.

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  Figure 3. Free from heart failure readmission (A) and probability of survival (B) after TAVR by extent of cardiac damage. HF indicates heart failure; and TAVR, transcatheter aortic valve replacement.

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  Figure 4. Adjusted subdistribution hazard ratios for predictors of early post‐TAVR heart failure readmission. Adjusted subdistribution hazard ratios and 95% CIs were estimated using a Fine–Gray subdistribution hazard model, accounting for the competing risk of death. The model included a random intercept at the hospital level to account for clustering. TAVR indicates transcatheter aortic valve replacement.